DLE prevents the kidney and intestine histopathology in hyperuricemic rats at the 9th week of administration. (a) Kidney damages directly reflected by hematoxylin-eosin (H & E) (x400). (b) Kidney damages directly reflected by Masson (x400). (c) Kidney damages directly reflected by periodic acid-schiff (PAS) (x 400). (d) Intestinal damages directly reflected by H&E (x200). (e) The data of kidney histopathology was semiquantitatively analysed. Normal, the normal control group; model, the model group; DLE-L, low dose of the macroporous resin extract of Dendrobium candidum leaves; DLE-H, high dose of the macroporous resin extract of Dendrobium candidum leaves. (f, g, and h) Villus height, depth of crypt, and ratio of villus height to depth of crypt of intestine. Normal, the normal control group; Model, the model group; DLE-L, low dose of the macroporous resin extract of Dendrobium candidum leaves; DLE-H, high dose of the macroporous resin extract of Dendrobium candidum leaves. The data were expressed as mean ± SD (n = 5). ∗∗p < 0.01 and ∗p < 0.05 versus the normal control group; ΔΔp < 0.01 and Δp < 0.05 versus the model group.