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. 2020 Feb 14;24:52. doi: 10.1186/s13054-020-2756-3

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Cox proportional hazard model for risk of death at day 28 for very early- (VE-VPs) and delayed-vasopressor support (D-VPs). The Cox proportional hazards model was adjusted by SOFA score at day 1, the presence of hyperlactatemia (septic shock according to Sepsis 3.0 definition), delay time of antibiotic administration, and the net fluid balance at 24 h. Very early VPs, vasopressor support initiated before or within the next hour of the first fluid resuscitation (FRLoad). Delayed VPs, vasopressor support initiated > 1 h of the first fluid resuscitation (FRLoad). VPs, start of vasopressor support