Fig. 4.

Gene expression of fibrosis markers after ischemia for 15, 25, 35 and 45 min and reperfusion for 24 h and 5 weeks. a: 24 h after ischemic injury gene expression of Tgf-β1 and Col1a1 significantly upregulated following ischemia for 35 and 45 min, whereas Laminin did not reveal significant upregulation in any treatment group following reperfusion for 24 h. b: After 5 weeks reperfusion Tgf-β1, Col1a1 and Laminin were significantly upregulated in the treatment groups of ischemia for 35 min and 45 min. Displayed are means with s.e.m. *P < 0.05 versus control