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. 2020 Feb 15;20:57. doi: 10.1186/s12883-020-01633-3

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© The Author(s) 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Forest plot of CGRP mAb vs. placebo for the changes in baseline monthly acute migraine-specifc medication days. The estimated pooled WMD was − 1.28 (95% CI, − 1.66 to − 0.90) with high statistical significance (P < 0.00001). There was high heterogeneity among the studies (I² = 77%). SD standard deviation, CI confidence interval, WMD weighted mean difference