Table 1. Correlations between HER2 and BRAF gene mutation and clinicopathological characteristics (n = 480).

Characteristics	Number	BRAF		P	HER2		P
		Mutation	%		Amplification	%
Gender
Male	288	10	3.47	0.51	18	6.25	0.55
Female	192	9	4.69		9	4.69
Age (year)
≤50	63	3	4.76	0.72*	5	7.94	0.38*
>50	417	16	3.84		22	5.28
Location
Right side colon	105	3	2.86	0.19*	5	4.76	0.99
Left side colon	87	7	8.05		6	6.90
Rectum	269	9	3.35		16	5.95
Mucin production
With	415	15	3.61	0.31*	23	5.54	0.77*
Without	65	4	6.15		4	6.15
Tumor differentiation
Poor	103	8	7.77	0.04*	5	4.85	0.71
Moderate/well	377	11	2.92		22	5.84
Tumor stage
I	66	2	3.03	0.62	0	0.00	0.013*
II	225	11	4.89		13	5.78
III	189	6	3.17		14	7.41
Bowel wall invasion (T)
T1+T2	90	2	2.22	0.55*	1	1.11	0.041*
T3+T4	390	17	4.36		26	667
Tumor diameter
<5 cm	261	7	2.68	0.18	14	5.36	0.97
≥5 cm	219	12	5.48		13	5.94
Lymph node metastasis (N)
With	189	6	4.47	0.48	13	6.88	0.17
Without	291	13	3.17		14	4.81
Lymphovascular invasion
No	332	14	4.22	0.66	17	5.12	0.47
Yes	148	5	3.38		10	6.76
Alcohol intake
Ever	99	2	2.02	0.39*	4	4.04	0.44
Never	381	17	4.46		23	6.03
Smoking
Ever	129	3	2.33	0.27	8	6.20	0.74
Never	351	16	4.56		19	4.69
Cancer family history
Yes	92	3	3.26	0.99	7	7.61	0.61
No	119	4	3.36		8	6.72
Unknown	269
Colorectal family history
Yes	29	0	0.00	0.59*	3	10.34	0.49*
No	182	7	3.85		12	6.59
Unknown	269
MSI status
MSI	72	4	5.56	0.51*	4	5.56	0.98*
MSS	408	15	3.68		23	5.63
RAS status
Mutation	207	0	0	0.001	2	3.48	0.001
Wildtype	273	19	6.95		25	9.12

Note:

^*Fisher exact test were used.