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. 2020 Feb 12;8:e8548. doi: 10.7717/peerj.8548

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©2020 Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.

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(A) Venn diagram of differentially expressed mRNAs (DEGs) in skeletal muscle of GK rats compared with aged-matched Wistar rats at the age of 3 and 4 weeks. (B) Venn diagram of differentially expressed lncRNAs (DELs) in skeletal muscle of GK rats compared with aged-matched Wistar rats at the age of 3 and 4 weeks. (C) The top 10 KEGG pathways of DEGs in GK rats compared with aged-matched Wistar rats at the age of 3 weeks. (D) The top 10 KEGG pathways of DEGs in GK rats compared with aged-matched Wistar rats at the age of 4 weeks. The 3wk_up_DEGs represents upregulated mRNAs at 3 weeks. The 4wk_up_DEGs represents upregulated mRNAs at 4 weeks. The 3wk_down_DEGs represents downregulated mRNAs at 3 weeks. The 4wk_down_DEGs represents downregulated mRNAs at 4 weeks. The 3wk_up_DELs represents upregulated lncRNAs at 3 weeks. The 4wk_up_DELs represents upregulated lncRNAs at 4 weeks. The 3wk_down_DELs represents downregulated lncRNAs at 3 weeks. The 4wk_down_DELs represents downregulated lncRNAs at 4 weeks.