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There is a decrease in the mediated SIRT1 deacetylation. (a) qPCR analysis of SIRT1 mRNA expression on heart tissue. (b) Representative western blot membrane of Ac lysine of heart tissue proteins and below the acetylation profile in heart tissue in fold change. For (a), n = 4 for all groups; for (a), n = 3 for all groups. The values are given as the mean and fold change ± SEM; ∗p < 0.05 vs. control; #p < 0.05 vs PAH.
