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. 2020 Feb 3;2020:9084567. doi: 10.1155/2020/9084567

Figure 2.

Figure 2

Exendin-4 ameliorated the progress of diabetic nephropathy and activated the renal AMPK pathway. The 24-hour urinary albumin (a) and 24-hour urinary 8-OH-dG (b) were measured by ELISA. (c) Periodic acid-Schiff (PAS) and Masson staining of kidney. Magnification ×400. (d–f) The renal mRNA expression of TGF-β1, Col-1, and FN, respectively (n = 6 per group). Western blot analysis of renal TGF-β1 (g, h) and AMPK (i, j) protein and the quantitative analysis results (n = 5 per group). n = 6~8 per group. ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001 vs. control group; #P < 0.05, ##P < 0.01, and ###P < 0.001 vs. DM+Exc group; &P < 0.05, &&P < 0.01, and &&&P < 0.001 vs. DM-Con group.