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. 2020 Feb 11;13:345–354. doi: 10.2147/JPR.S238458

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© 2020 Tyrtyshnaia and Manzhulo.

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The results of dendrite Sholl analysis and spines density measurement. (A) Number of intersections along the apical dendritic trees at all distances from the soma in CA1 pyramidal neurons, Mean ± SEM, n=5 (number of animals). (B) The total number of branches (left, *p=0.0317) and the total length of apical dendrites (right, *p=0.0317) of CA1 pyramidal neurons, n=5 (number of animals). (C) The number of intersections along the basal dendritic trees at all distances from the soma of CA1 pyramidal neurons, n=5 (number of animals). (D) The total number of branches (left, p=0.22) and the total length of basal dendrites (right, p=0.84) of CA1 pyramidal neurons, n=5 (number of animals). (E) Number of Sholl intersections along the basal dendritic trees at all distances from the soma of DG granule neurons, n=5 (number of animals). (F) The total number of branches (left, *p=0.0159) and the total length of dendrites (right, *p=0.0159) of DG granule neurons, n=5 (number of animals). (G) Density of CA1 pyramidal neurons dendritic spines: total – left (**p=0.0014), mushroom – right (***P<0.0001), n=15 (number of analyzed neurons). (H) Density of DG granule neurons dendritic spines: total – left (*p=0.0283), mushroom – right (**p=0.006), n=15 (number of analyzed neurons). (I) The images of CA1 pyramidal neurons stained by the Golgi-Cox method from the Sham (upper) and CCI (lower) groups. (J) The images of DG granule neurons stained by the Golgi-Cox method from Sham (upper) and CCI (lower) groups. (K) The images of dendritic spines in the CA1-region and DG in Sham (left) and CCI (right) groups.