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. 2020 Feb 11;12:921–929. doi: 10.2147/CMAR.S239326

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© 2020 Liu et al.

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Low expression circHIPK3 suppressed GEM-resistant PC cells’ proliferation, invasive, migration, and enhance cell apoptosis. (A) CCK8 assay showed that negative control or circHIPK3 knockdown could significantly inhibit PANC-1-GEM and SW 1990-GEM cells’ proliferation. (B–E) Wound healing, transwell assays showed that negative control or circHIPK3 knockdown could significantly inhibit PANC-1-GEM and SW 1990-GEM cells’ invasive, migration. (F, G) Flow cytometry showed that negative control or circHIPK3 knockdown could significantly inhibit PANC-1-GEM and SW 1990-GEM cells’ apoptosis. (H) BALB/c nude mice injected with PANC-1/GEM cells transfected with negative control or circHIPK3 knockdown could significantly inhibit PANC-1-GEM tumor Xenografts in vitro and analysis of tumor volume of mice measured every week. Data represent mean ± SD. *P < 0.05 represents compared with control group. ^#P < 0.05 represents compared with GEM-resistant group.