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. Author manuscript; available in PMC: 2020 May 6.
Published in final edited form as: Oncogene. 2019 Nov 6;39(7):1402–1413. doi: 10.1038/s41388-019-1088-8

Fig 4. Context dependent TAK1 signaling in cancer biology.

Fig 4.

Signal transduction through multiple signal transduction systems regulate TAK1 activity. These include receptor signaling, as well as cell stress pathways such as DNA damage. TAK1 integrates these signals and mediates downstream signaling through multiple pathways. These include MAPK and NFκB signaling, microtubule acetylation, and cellular redox homeostasis. Perturbations to TAK1 activity result in diverse phenotypes and are found across multiple types of cancer.