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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: Med Sci Sports Exerc. 2020 Mar;52(3):589–597. doi: 10.1249/MSS.0000000000002174

Table 2.

Differentially methylated CpGs non-linearly associated with physical activity (PA). P-values of the significant associations with moderate-vigorous-intensity PA (MVPA) are given for the discovery, validation and meta-analysis stage of the main analysis. P-values of the meta-analysis with the Fisher and Stouffer methods are provided. Significant associations in the discovery population are those with a p-value <10−5, while significant associations in the meta-analysis are those with a p-value <1.185·10−7.

Genomic information Discovery Validation Meta-analysis
CpG Chr* Position (bp) Gene P-value P-valueREG P-valueFOS P-valueFisher P-valueStouffer
cg24155427 1 31,242,051 NA 4.97·10−08 2.49·10−04 2.55·10−01 1.19·10−09 2.29·10−08
cg09565397 8 145,543,014 DGAT1 1.81·10−06 1.23·10−03 2.91·10−01 1.59·10−07 1.06·10−06
*

CpG, CpG ID; Chr, chromosome location; Position (bp), basepair genomic position; NA, non-annotated gene; REG, REGICOR; FOS, Framingham Offspring Cohort.