Skip to main content
. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: Environ Int. 2020 Jan 8;136:105440. doi: 10.1016/j.envint.2019.105440

Table 2.

Associations between Residential Levels of Ambient Air Pollutants and APOE-ε4 Status on Cognitive Decline

NO2 PM2.5 PM10 APOE-ε4
Change in Cognitive Scores1 95% CI Change in Cognitive Scores1 95% CI Change in Cognitive Scores1 95% CI Change in Cognitive Scores2 95% CI
Global Cognition −0.075 −0.10, −0.05 −0.093 −0.12, −0.07 −0.046 −0.06, −0.03 −0.048 −0.07, −0.03
Memory Domain −0.037 −0.06, −0.01 −0.047 −0.08, −0.02 −0.022 −0.04, −0.003 −0.049 −0.05, −0.05
Language Domain −0.055 −0.08, −0.03 −0.066 −0.10, −0.03 −0.025 −0.04, −0.01 −0.059 −0.08, −0.03
Executive Function −0.031 −0.06, −0.01 −0.051 −0.08, −0.02 −0.023 −0.04, −0.01 −0.040 −0.06, −0.02

All models adjusted for individual (age, education, sex, race/ethnicity), neighborhood sociodemographic variables (Census based SES z-score), and a cohort indicator to adjust for secular trends. All models weighted by the product of the IPW and IPCW weights.

1

Expressed as a standard deviation change in the rate of decline in cognitive score associated with an IQR change in pollutant.

2

Expressed as a standard deviation change in the rate of decline in cognitive score associated with being APOE-ε4 positive

HHS Vulnerability Disclosure