Table 3.
Association between Ambient Air Pollution and Cognitive Decline by APOE-ε4 status
| NO2 | PM2.5 | PM10 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Change in Cognitive Scores1 | 95% CI | p-value2 | Change in Cognitive Scores1 | 95% CI | p-value2 | Change in Cognitive Scores1 | 95% CI | p-value2 | |
| Global Cognitive Score | |||||||||
| APOE-ε4 − | −0.069 | −0.09, −0.05 | <0.001 | −0.088 | −0.12, −0.06 | <0.001 | −0.039 | −0.06, −0.02 | <0.001 |
| APOE-ε4 + | −0.085 | −0.11, −0.06 | −0.104 | −0.13, −0.08 | −0.057 | −0.07, −0.04 | |||
| Memory Domain | |||||||||
| APOE-ε4 − | −0.033 | −0.06, −0.01 | 0.03 | −0.043 | −0.07, −0.01 | 0.02 | −0.018 | −0.04, 0.001 | 0.02 |
| APOE-ε4 + | −0.043 | −0.07, −0.02 | −0.053 | −0.09, −0.02 | −0.029 | −0.05, −0.01 | |||
| Executive Function Domain | |||||||||
| APOE-ε4 − | −0.025 | −0.05, 0.001 | <0.001 | −0.047 | −0.08, −0.02 | <0.01 | −0.018 | −0.04, 0.003 | <0.001 |
| APOE-ε4 + | −0.040 | −0.07, −0.01 | −0.061 | −0.09, −0.03 | −0.033 | −0.05, −0.01 | |||
| Language Domain | |||||||||
| APOE-ε4 − | −0.046 | −0.07, −0.02 | <0.001 | −0.059 | −0.09, −0.03 | <0.001 | −0.017 | −0.04, 0.001 | <0.001 |
| APOE-ε4 + | −0.066 | −0.09, −0.04 | −0.078 | −0.11, −0.05 | −0.038 | −0.06, −0.02 | |||
All models adjusted for individual (age, education, sex, race/ethnicity), neighborhood sociodemographic variables (Census based SES z-score), and a cohort indicator to adjust for secular trends. All models weighted by the product of the IPW and IPCW weights.
1
Expressed as a standard deviation change in the rate of decline in cognitive score associated with an IQR change in pollutant
2
p-values for cross-product terms for interaction in the association of air pollutants and cognition