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. Author manuscript; available in PMC: 2021 Jul 1.
Published in final edited form as: ASAIO J. 2020 Jul;66(7):818–824. doi: 10.1097/MAT.0000000000001057

Figure 1: Extracorporeal bypass circuit.

Figure 1:

Blood drained (by gravity) into the open venous reservoir. Blood exiting the reservoir was pumped either through a polypropylene membrane oxygenator by the systemic roller pump (P1) back into the animal or diverted by a second roller pump (P2) to create an air: blood interface shunt that was recirculated back to the venous reservoir. The air- blood interface was controlled by a Hoffmann clamp to expose the blood to a negative pressure of 100 mmHg. A pressure relief valve opened to introduce air into the shunt at −100 mmHg.