Table 2.

Comparison of synovial fluid biomarker concentrations between the 2 clusters. Values are presented as mean ± standard deviation or number (%)^*

	Dysregulated Inflammation Cluster	Low Inflammation Cluster	p†
Cytokine Concentrations
IL-1α (pg/mL)	0.92 ± 2.11	0.32 ± 0.47	0.39
# < LLOD	5/10 (50%)	19/25 (76%)	0.23
IL-1β (pg/mL)	1.30 ± 2.63	0.17 ± 0.25	0.21
# < LLOD	2/10 (20%)	13/25 (52%)	0.13
IL-1RA (pg/mL)	15,988 ± 14,012	4,653 ± 6,420	0.03
IL-1RA:IL-1β ratio	49,814 ± 40,816	126,632 ± 178,787	0.053
Cartilage Degradation
CTX-II (ng/mL)	0.74 ± 0.38	0.84 ± 0.44	0.54
COMP (μg/mL)	52.0 ± 11.6	52.0 ± 12.3	> 0.99
sGAG (μg/mL)	441.3 ± 149.5	323.1 ± 135.9	0.03
MMP-1 (pg/mL)	1,057,992 ± 285,749	178,556 ± 178,658	< 0.001
MMP-3 (pg/mL)	2,551,651 ± 2,154,629	927,773 ± 410,839	0.04
MMP-9 (pg/mL)	13,185 ± 7,792	40,095 ± 46,222	0.009
Bone Turnover
NTX-I (μg/mL)	19.7 ± 9.8	21.2 ± 6.3	0.68
Hemarthrosis
Bilirubin+Biliverdin (μmol/L)	32.1 ± 14.1	31.0 ± 26.1	0.91

^*Bold, italics denotes statistically significant differences between patient clusters

^†Raw non-transformed data presented in this table; however, transformed data were used for statistical analyses