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. Author manuscript; available in PMC: 2021 Feb 14.
Published in final edited form as: ACS Infect Dis. 2019 Dec 19;6(2):168–172. doi: 10.1021/acsinfecdis.9b00441

Figure 1.

Figure 1

Figure 1

Figure 1

A Chemical structures of 4,5-, and 4,6-aminoglycosides, of propylamycin, apramycin, and an apralog.

B View of the three-dimensional structure of the A-site loop within rRNA helix 44, the drug binding pocket, complexed with 4,5- and 4,5-disubstituted AGAs: the common neamine core is denoted in yellow; ring III of the 4,6-compounds (kanamycin) is denoted in red; rings III and IV of the 4,5-compounds (paromomycin) are denoted in blue. Indicated are the polymorphic residues (1408, 1491) and G1405, the target for methylation by RMTases.

C AMEs Acting on the 4,6-AGA Kanamycin B