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. Author manuscript; available in PMC: 2021 Feb 1.
Published in final edited form as: Virology. 2019 Dec 30;541:160–173. doi: 10.1016/j.virol.2019.12.011

Figure 7. vIRFs do not disrupt the CBP-IRF3 interaction and are not needed for efficient silencing of type I IFN expression during lytic reactivation.

Figure 7.

iSLK-BAC16 and iSLK-BAC16-ΔvIRF cell lines were lytically reactivated using 1 μg/ml Dox and 1 mM NaB for 40 hpi and then challenged with SeV infection. (A) IFNβ gene expression in the absence of SeV. (B) IFNβ gene expression after SeV (1 HA/ml) infection for 8 hours. Error bars represent standard deviation (n=3). (C) Analyzing the expression of phosphorylated IRF3 (pIRF3 S396) in cell lysates. (D) CBP and control IgG immunoprecipitations testing for CBP and IRF3.