Figure 1.

Schematic structure of EGFR^WT (a) and EGFR^vIII (b). Both receptors are composed of extracellular (I–IV), transmembrane, and intracellular domains, and the major difference is deletion of exons 2–7 encoding extracellular domains I and II in mutated receptor. As a result of deletion, EGFR^vIII is unable to bind known ligands and shows enhanced stability in cell membrane.