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. 2019 Dec 16;2019:1092587. doi: 10.1155/2019/1092587

Table 2.

Issues addressed in the article (except therapies in Table 1).

EGFRvIII issue/process Mechanism/way to address Selected references
EGFRvIII presence in tumors/cancers GB in about 40%, rarely in HNCSCC, lung prostate, colorectal cancer, breast cancer [27, 33–41, 43]
EGFRvIII mechanism of mutation Deletion of EGFR exons 2–7 [26–29, 43]
EGFRvIII mechanism of action Several models:
(1) Heterodimerization with EGFRWT
(2) Homodimerization
(3) EGFRvIII and MET cooperation, FAK involved
(4) OSMR mechanism
Resistant to degradation important for all models		 [16, 17, 121–126, 142, 143]
EGFRvIII biological role Extreme opinions: from lack of important role at advanced cancer (tumor) stages, to role in self-renewal, survival, and proliferation of cancer stem cells [33, 147, 150, 152–158, 164, 165]
EGFRvIII cell culture models 3D primary cell cancer cell models, DK-MG model, genetically modified cancer cell lines [21, 150, 153, 167, 242–244, 246–248]