Table 3.
Diagnostic values of GP73 for liver necroinflammation in NASH patients.
| Stage | AUC | 95% CI | Cutoff | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Youden index | P |
|---|---|---|---|---|---|---|---|---|---|
| GP73 | |||||||||
| G ≥ 2 | 0.742 | 0.676-0.801 | 94.57 | 44.74 | 92.80 | 79.07 | 73.42 | 0.375 | <0.0001 |
| G = 3 | 0.891 | 0.840-0.931 | 101.1 | 88.89 | 85.94 | 22.87 | 99.40 | 0.748 | <0.0001 |
| ALT | |||||||||
| G ≥ 2 | 0.609 | 0.538-0.677 | 80.00 | 59.21 | 63.20 | 49.45 | 71.82 | 0.224 | 0.009 |
| G = 3 | 0.576 | 0.505-0.646 | 110.00 | 66.67 | 56.77 | 6.75 | 97.32 | 0.234 | 0.457 |
| AST | |||||||||
| G ≥ 2 | 0.667 | 0.597-0.731 | 54.00 | 47.37 | 76.80 | 55.38 | 70.60 | 0.242 | <0.0001 |
| G ≥ 3 | 0.704 | 0.636-0.766 | 76.00 | 77.78 | 58.33 | 8.05 | 98.24 | 0.361 | 0.011 |
Abbreviation: AUC = area under the receiver operating characteristic curve; PPV = positive predictive value; NPV = negative predictive value; GP73 = Golgi protein 73; ALT = alanine transaminase; AST = aspartate aminotransferase.