Table 3.
Gut microbiota profiles that correlated with uroguanylin immunoreactive cells density in the duodenal villi and crypts of patients with irritable bowel syndrome before and after fecal microbiota transplantation.
| Bacterial strain | Bacterial signals | P ∗ | Correlations with uroguanylin cells density (r, P∗∗) | ||
|---|---|---|---|---|---|
| Before FMT | After FMT | Before FMT | After FMT | ||
| Total IBS group | |||||
| Bacteroides fragilis | 39 ± 23 | 37 ± 16 | 0.72 | Crypts (-0.81, 0.02) | — |
| Parabacteroides | 7.9 ± 3 | 14.6 ± 5 | 0.24 | — | Crypts (0.796, 0.01) |
| Alistipes | 107 ± 25 | 127 ± 27 | 0.2 | — | Crypts (0.71, 0.038) |
| Streptococcus sanguinis and S. thermophilus | 171 ± 80 | 78 ± 42 | 0.59 | — | Villi (0.69, 0.047) |
| PI-IBS group | |||||
| Bacteroides fragilis | 65 ± 26 | 36 ± 28 | 0.4 | Villi (0.94, 0.02) | — |
| Escherichia/Shigella | 141 ± 104 | 181 ± 135 | 0.4 | Crypts (0.94, 0.02) | — |
Comparison: Paired t-test. Data are presented as the mean ± SEM. Spearman's correlation test (r) was used to correlate between the bacterial strain and uroguanylin immunoreactive cells density in the duodenal villi and crypts. ∗Comparison between the signals before and after FMT; ∗∗P values for correlations. FMT: fecal microbiota transplantation; IBS: irritable bowel syndrome; PI: post infectious.