Table 4.
Effects of curcumin treatment on invasive capacity of native and double-resistant non-small cell lung cancer (NSCLC) cell lines when in organotypic co-culture with MRC5 fibroblasts. Co-cultures were performed in triplicate on three separate occasions.
| Mean Percent Reduction in Invaded Area (±SD) | ||||||
|---|---|---|---|---|---|---|
| Curcumin Concentration (μM) | A549 | A549cisR/pemR | PC9 | PC9cisR/pemR | PC9ER | PC9ERcisR/pemR |
| 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 0.25 | 2.13 (±3.25) | 0.43 (±3.80) | 0.62 (±6.01) | 19.62 (±3.17) | 0.30 (±1.51) | 36.66 (±1.29) |
| 0.5 | 5.71 (±3.02) | 2.88 (±3.93) | 6.05 (±2.27) | 21.14 (±1.97) | 7.82 (±5.33) | 12.92 (±0.45) |
| 1.0 | 3.05 (±0.8) | 18.87 (±1.86) | 6.00 (±0.74) | 35.73 (±1.68) | 2.95 (±11.08) | 20.13 (±1.89) |
| 2.5 | 5.31 (±3.06) | 16.10 (±1.76) | 4.46 (±4.10) | 34.02 (±4.03) | 5.26 (±4.20) | 31.41 (±1.12) |
| 5.0 | 6.73 (±0.61) | 20.33 (±2.45) | 9.83 (±7.10) | 53.02 (±0.55) | 8.35 (±5.52) | 56.59 (±0.92) |