Skip to main content
. 2020 Jan 9;18(1):45. doi: 10.3390/md18010045

Figure 5.

Figure 5

Inhibition of intracellular signals on cell growth and phosphorylation of target proteins in ovarian cancer cell. (A) The growth of ES-2 and OV-90 cells was observed by treatment of fucoidan (300 μg/mL) or a combination of fucoidan with LY294002 (blockage of AKT), U0126 (blockage of ERK1/2), SB203580 (blockage of P38), or SP600125 (blockage of JNK) for 48 h. (B–H) Repression of inhibitors on the activation of (B) p-cyclin D1, (C) p-AKT, (D) p-P70S6K, (E) p-S6, (F) p-ERK1/2, (G) p-JNK, and (H) p-P38 in both ES-2 and OV-90 cells. The values of graph were calculated compared with vehicle-treated cells. *** p < 0.001, ** p < 0.01, and * p < 0.05 indicate significant effects of each treatment compared with vehicle-treated control cells. # indicates significant effects (p < 0.05) as compared to fucoidan alone.