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The antimalarial activity of compounds derivatives 6.
| Plasmodium falciparum 3D7 Strain | Plasmodium falciparum W2 Strain | HUVEC Cells | Selectivity Index (3D7) | Selectivity Index (W2) | |
|---|---|---|---|---|---|
| Compounds | IC50 ± SD (nM) | IC50 ± SD (nM) | CC50 nM ± SD | =CC50/IC50 | =CC50/IC50 |
| 6a | 34.46 ± 9.25 | 61.37 ± 11.12 | nd | nd | nd |
| 6b | 17.42 ± 7.7 | 30.35 ± 6.09 | >100 | >17.5 | >10.8 |
| 6c | >100 | >100 | / | / | / |
| 6d | >100 | >100 | / | / | / |
| CQ | 22.38 ± 3.24 | 134.12 ± 32.29 | 37.56 ± 1.24 | 1.7 | 0.3 |
