Table 4.
The antimalarial activity of the target compounds.
| Plasmodium falciparum 3D7 Strain | Plasmodium falciparum W2 Strain | HUVEC Cells | Selectivity Index (3D7) | Selectivity Index (W2) | |
|---|---|---|---|---|---|
| Compounds | IC50 ± SD (nM) | IC50 ± SD (nM) | CC50 nM ± SD | =CC50/IC50 | =CC50/IC50 |
| 10 | 25.37 ± 2.88 | 42.14 ± 6.73 | >100 | >8.9 | >5.3 |
| 12a | 36.9 ± 6.59 | 11.06 ± 4.82 | 100 ± 0.008 | 2.85 | 5.7 |
| 12b | 34.45 ± 7.36 | 38.95 ± 3.66 | >100 | >6.9 | >6.1 |
| 12c | >100 | >100 | / | / | / |
| 12d | 13.64 ± 2.47 | 166.87 ± 9.64 | nd | nd | nd |
| 13a | >100 | >100 | / | / | / |
| 13b | 4.19 ± 1.12 | 13.30 ± 2.01 | 112 ± 0.008 | 26.7 | 8.4 |
| 13c | 44.17 ± 3.9 | 28.57 ± 1.91 | >100 | >4.4 | >6.8 |
| 13d | >100 | >100 | / | / | / |
| 14a | 20.72 ± 7.69 | 32.33 ± 9.97 | 52 ± 0.004 | 2.5 | 1.6 |
| 14c | 50.33 ± 3.8 | 18.97 ± 7.30 | >100 | >4.2 | >11.3 |
| 14d | 14.85 ± 4.48 | 23.45 ± 4.66 | 100 ± 0.005 | 6.83 | 4.3 |
| 15a | ˃100 | ˃100 | / | / | / |
| 16a | ˃100 | ˃100 | / | / | / |
| 17a | 37.63 ± 7.85 | 47.84 ± 5.83 | nd | nd | nd |
| 17b | ˃100 | ˃100 | / | / | / |
| 17c | 14.65 ±2.55 | 36.88 ± 2.99561 | nd | nd | nd |
| 17d | ˃100 | ˃100 | / | / | / |
| CQ | 22.38 ± 3.24 | 134.12 ± 32.29 | 37.56 ± 1.24 | 1.7 | 0.3 |