Table 6.
Levels of factors used in Box–Behnken design (BBD).
| Factors | Range and Level | ||
|---|---|---|---|
| −1 | 0 | 1 | |
| X1 (the mass ratio of drug-to-SPC) | 0.5:1 | 1:1 | 1.5:1 |
| X2 (the mass ratio of SPC-to-Chol) | 2:1 | 4:1 | 6:1 |
| X3 (the concentration of SPC) | 12 mg/mL | 14 mg/mL | 16 mg/mL |
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