Table 3.

Examples of different ORI polymer nanoparticles.

Delivery Systems	Administration	Results	Ref.
ORI-PLA-NPs	Intravenous administration in mice at a dose of 25 mg/kg	High concentration of ORI in liver, lung and spleen	[78]
ORI-PCL-PEO-PCL-NPs	Intravenous administration in H22 tumor-bear mice at a dose of 8 mg/kg	Tumor volume and weight decreased, and the survival rate increased to 169.6%	[80,81]
ORI-PLA-RGD-NPs	Intravenous administration in the H22 tumor-bear mice at a dose equivalent to 20 mg/kg of ORI	Enhanced targeting effect; tumor volume and weight were significantly reduced (p < 0.01), with average survival length extended from 27 days to 41 days compared with ORI-PLA-NP	[82]
ORI-GC-NPs	Intravenous administration in mice at a dose of 1 mg/kg	Prolonging MRT0–t from 3.415 h to 14.042 h, liver AUC0–t increasing by 6.4-fold compared with ORI solution	[84]
ORI-GB-NPs	Intravenous administration on Wistar rats at a dose of 14 mg/kg and Kunming strain mice at 20 mg/kg	The retarded in vitro release with increasing of crosslinking agent glutaraldehyde; liver active targeting; enhancing the drug plasma concentration and prolonging the circulation time	[85,86]
ORI-Gal-PT-NPs	Treating HepG2 cells at concentrations of 5.0, 7.5, 10 and 12.5 mg/mL	The apoptosis increasing by 4−5.6% compared with ORI solution	[87]

MRT = Mean Retention time.