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. 2020 Jan 15;25(2):360. doi: 10.3390/molecules25020360

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) The structure of Hsp90–Cdc37-Cdk4 complex (Hsp90 protomers A and B are in red and gray, respectively, Cdc37 is in green, and Cdk4 is in blue). (B) The structure of Hsp90B–Cdc37 (Hsp90B in grey, Cdc37 in green). The fragment of Cdc37 that was selected by the PepCrawler algorithm for the inhibitory peptide is marked in red. (C) The molecular surface of Hsp90B (grey), in the complex with the Cdc37p4 peptide retrieved by PepCrawler (green). (D) The molecular surface of Hsp90 (in grey), in complex with the Pep-Whisperer-designed peptide Cdc37p5 (magenta).