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Substrate scope of the Mukaiyama aldol condensation reaction of 11a and 11b with aldehydes.
| Entry. | SM | R2 | 12 (E:Z) a | Yield (%) |
|---|---|---|---|---|
| 1 | 11a | CO2Et | 12a (5:1) | 96 |
| 2 | 11b | CO2Et | 12b (5:1) | 85 |
| 3 | 11a | 4-MeC6H4 | 12c (> 1:1) | 45 |
| 4 | 11a | 3-FC6H4 | 12d (> 10:1) | 63 |
| 5 | 11a | 4-ClC6H4 | 12e (> 10:1) | 65 |
| 6 | 11a | 4-NO2C6H4 | 12f (6:1) | 80 |
| 7 | 11a | 2-Furyl | 12g (> 10:1) | 80 |
| 8 | 11a | C6H5 | 12h (> 10:1) | 60 |
| 9 | 11b | C6H5 | 12i (E:Z) a | 42 |
a Ration at C11 were determined by 1H NMR spectroscopy.
