Table 4.
NaV-inhibitory activity of 9, 31, 32, and 33a in a cell-based assay with Neuro 2A cells.
| Compound | IC50 (mean ± SD) (nM) | n |
|---|---|---|
| dcSTX (3) | 89 ± 36 | 3 |
| SEA (9) | 47 ± 12 | 3 |
| dcSEA (31) | 5700 ± 3.1 | 3 |
| SEE (32) | 185 ± 74 | 4 |
| 11-benzylidene STX (33a) | 16 ± 6.9 | 5 |
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