Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
NaV-inhibitory activities of 33a–f, using whole-cell, patch-clamp recording.
| Compound | hNaV1.2 | hNaV1.5 | hNaV1.7 |
|---|---|---|---|
| 11-benzylidene STX (33a) | 5.2 ± 6.0 | 94.1 ± 12.0 | 124.1 ± 20.6 |
| 11-methylbenzylidene STX (33b) | 22.9 ± 8.6 | >300 | >300 |
| 11-fluorobenzylidene STX (33c) | 7.7 ± 1.6 | >300 | >300 |
| 11-nitrobenzylidene STX (33d) | 8.79 ± 0.96 | 50.9 ± 7.8 | >300 |
| 11-furfuryl STX (33e) | 542.7 ± 65.7 | >300 | >300 |
| 11-metoxybenzylidene STX (33f) | 45.0 ±2.72 | >300 | >300 |
IC50 (mean ± SD) (nM).
