Table 1.
Translational diffusion coefficients (DT) and relaxation times (τT) of water for untreated and Pd2Spm- and cisplatin-treated (at 8 µM) D2O-DNAhyd and H2O-DNAhyd (at 298 K) for the dynamics of DNA’s backbone (Q-dependent) and the water motions within the spine of hydration (Q-independent). The translational diffusion coefficients and relaxation times of hydration water and fast localised motions in the picosecond timescale, formerly obtained for these systems, are also shown (shaded columns).
| Sample | Backbone | H2O/Spine Hydration | H2O/Hydration Shell a | Fast Localised Motions a |
||
|---|---|---|---|---|---|---|
| DT (×10−5 cm2 s−1) | τT (ns) | τT (ns) | DT (×10−5 cm2 s−1) | τT (ps) | τT (ps) | |
| D2O-DNAhyd | 1.0621 ± 0.0291 | 0.6607 ± 0.0221 | _ | _ | _ | _ |
| D2O-DNAhyd + cisplatin | 0.5532 ± 0.0322 | 0.8557 ± 0.0784 | _ | _ | _ | _ |
| D2O-DNAhyd + Pd2Spm | 1.2267 ± 0.0962 | 0.4796 ± 0.0594 | _ | _ | _ | _ |
| H2O-DNAhyd | 1.0621 ± 0.0291 | 0.6607 ± 0.0221 | 0.1995 ± 0.0223 | 0.723 ± 0.002 | 10.13 ± 0.32 | 3.591 ± 0.006 |
| H2O-DNAhyd + cisplatin | 0.5532 ± 0.0322 | 0.8557 ± 0.0784 | 0.1550 ± 0.0173 | 0.901 ± 0.004 | 7.40 ± 0.36 | 3.270 ± 0.003 |
| H2O-DNAhyd + Pd2Spm | 1.2267 ± 0.0962 | 0.4796 ± 0.0594 | 0.2067 ± 0.0112 | 0.744 ± 0.004 | 8.38 ± 0.86 | 3.387 ± 0.002 |
a From ref. [12].