Table 4.
Molecular classification of the breast cancer/ normal cells.
| Cell Lines | Molecular Classification | Years | Source and Disease | |||
|---|---|---|---|---|---|---|
| Name | Subtypes | ER | PR | HER2 | ||
| MDA-MB-453 | HER2 | + | 1976 | Female, 48 years, Caucasian, pericardial effusion, metastatic carcinoma | ||
| BT-549 | Basal-like | − | − | − | 1978 | Female, 72 years, Caucasian, breast, ductal carcinoma [59] |
| MDA-MB-361 | Luminal B | + | − | + | 1974 | Female, 40 years, Caucasian, brain, adenocarcinoma [60,61] |
| HS578T | Basal-like | − | − | − | 1977 | Female, 74 years, Caucasian, breast, carcinoma [62] |
| Bcap-37 | Luminal A | + | + | − | 1981 | Female, 48 years, Chinese, breast, medullary carcinoma [63] |
| HCC1395 | Basal-like | − | − | − | 1998 | Female, 43 years, Caucasian, breast/duct, ductal carcinoma [34,64] |
| BT-483 | Basal-like | − | − | − | 1978 | Female, 23 years, Caucasian, breast, ductal carcinoma [65,66] |
| SK-BR-3 | HER2 | − | − | + | 1970 | Female, 43 years, Caucasian, pleural effusion, adenocarcinoma [67] |
| BT-20 | Basal-like | − | − | − | 1958 | Female, 74 years, Caucasian, breast, carcinoma [68] |
| ZR-75-30 | Luminal A | + | + | − | 1978 | Female, 47 years, Black, ascites, ductal carcinoma [69] |
| HCC1806 | Basal-like | − | − | − | 1998 | Female, 60 years, Black, breast, squamous carcinoma [34,64] |
| MCF-7 | Luminal A | + | + | − | 1973 | Female, 69 years, Caucasian, pleural effusion, adenocarcinoma [59,60,70] |
| AU565 | HER2 | − | − | + | 1970 | Female, 43 years, Caucasian, malignant pleural effusion, malignant pleural effusion [67] |
| HCC1937 | Basal-like | − | − | − | 1998 | Female, 23 years, Caucasian, breast/duct, ductal carcinoma [64,71] |
| MDA-MB-231 | Basal-like | − | − | − | 1974 | Female, 51 years, Caucasian, pleural effusion, adenocarcinoma [60,61] |
| MDA-MB-157 | Basal-like | − | − | − | 1972 | Female, 44 years, Black, breast/medulla, medullary carcinoma [72] |
| BT-474 | Luminal B | + | + | + | 1978 | Female, 60 years, Caucasian, breast/duct, ductal carcinoma [59,65,66] |
| MCF-12A | Normal | 1992 | Female, 60 years, Caucasian, breast, fibrocystic, disease [66] | |||
| MCA-10A | Normal | 1984 | Female, 36 years, Caucasian, breast, fibrocystic, disease [37,66] | |||
| HS578BST | Normal | 1977 | Female, 74 years, Caucasian, breast, normal [62] | |||
ER: Estrogen receptor; PR: Progesterone Receptor; HER2: Human Epidermal Growth Factor Receptor2. MCF-12A, MCF-10A and HS578BST were considered human normal mammary gland epithelial cell lines, others were breast cancer cells.