Table 1.
The producing strain, biological activities of these heterocyclic alkaloids (1–130).
| NO. | Producing Strain | Environmental Source | Biological Activities | Ref. |
|---|---|---|---|---|
| 1 | A. sp. SCSIO 41501 | the gorgonian Melitodes squamata collected from the South China Sea, Sanya, China | moderate antiviral activity against HSV-1 under non-cytotoxic concentrations against Vero cells | [23] |
| 2 | A. terreus | the coral Sarcophyton subviride collected from the coast of Xisha Island in the South China Sea | potent inhibition on LPS-induced NO production; nonsignificant inhibition on α-Glucosidase | [24] |
| 3 | A. candidus KUFA0062 | the marine sponge Epipolasis sp. collected at Similan Island National Park (15–20 m), Thailand | weak cytotoxic activity against eight cell lines; nonsignificant antibacterial activity | [25] |
| 4 | A. alabamensis EN-547 | the fresh inner tissue of marine alga Ceramium japonicum collected at Qingdao, China | moderate antimicrobial activities against E. coli, M. luteus, Ed. ictaluri and V. alginolyticus | [26] |
| 5 | A. alabamensis EN-547 | the fresh inner tissue of marine alga Ceramium japonicum collected at Qingdao, China | moderate antimicrobial activities against E. coli, M. luteus, Ed. ictaluri and V. alginolyticus | [26] |
| 6 | A. sp. MEXU 27854 | sandy soil collected in the intertidal zone located in Caleta Bay, Acapulco, Guerrero, Mexico | nonsignificant cytotoxic activities | [27] |
| 7 | A. sp. MEXU 27854 | sandy soil collected in the intertidal zone located in Caleta Bay, Acapulco, Guerrero, Mexico | no biological activity was tested | [27] |
| 8 | A. sp. MEXU 27854 | sandy soil collected in the intertidal zone located in Caleta Bay, Acapulco, Guerrero, Mexico | nonsignificant cytotoxic activities | [27] |
| 9 | A. sp. MEXU 27854 | sandy soil collected in the intertidal zone located in Caleta Bay, Acapulco, Guerrero, Mexico | no biological activity was tested | [27] |
| 10 | A. sp. MEXU 27854 | sandy soil collected in the intertidal zone located in Caleta Bay, Acapulco, Guerrero, Mexico | no biological activity was tested | [27] |
| 11 | A. sp. CMB-M081F | the marine sediment collected at an intertidal depth of 1 m near Shorncliffe, Queensland, Australia | nonsignificant cytotoxic activities; potent inhibition on P-glycoprotein-mediated drug efflux | [28] |
| 12 | A. sp. KMM 4676 | an unidentified colonial ascidian (Shikotan Island, Pacific Ocean) | potent cytotoxicity against 22Rv1, while moderate cytotoxicity against PC-3 and LNCaP | [29] |
| 13 | A. sp. KMM 4676 | an unidentified colonial ascidian (Shikotan Island, Pacific Ocean) | no biological activity was tested | [29] |
| 14 | A. sp. KMM 4676 | an unidentified colonial ascidian (Shikotan Island, Pacific Ocean) | nonsignificant cytotoxic activities against PC-3, LNCaP and 22Rv1 cell lines | [29] |
| 15 | A. sp. KMM 4676 | an unidentified colonial ascidian (Shikotan Island, Pacific Ocean) | no biological activity was tested | [29] |
| 16 | A. nidulans EN-330 | The marine red alga P. scopulorum var. villum collected from Yantai coastline of north China | moderate antimicrobial activities against four human- and aqua-pathogens | [30] |
| 17 | A. nidulans EN-330 | The marine red alga P. scopulorum var. villum collected from Yantai coastline of north China | weak antimicrobial activities against four human- and aqua-pathogens | [30] |
| 18 | A. sp. SCSIO XWS03F03 | a sponge collected from the sea area Xuwen County, Guangdong, China | potent cytotoxic activity against HL-60 and LNCap cell lines | [31] |
| 19 | A. sp. | the sponge Tethya aurantium (Pallas 1766) collected at the entrance of Limski kanal (a depth of 20 m) | moderate selective activity against marine bacteria; nonsignificant cytotoxicity against L5178Y cells | [32] |
| 20 | A. versicolor LZD-14-1 | the gorgonian Pseudopterogorgia sp. (LZD-14) collected from the South China Sea | weak cytotoxic activity against A549; potent inhibitory activity against TrxR | [33] |
| 21 | A. flavus OUCMDZ-2205 | the prawn Penaeus vannamei collected in Lianyungang sea area, Jiangsu Province of China | moderate antibacterial and cytotoxic activities, as well as PKC-beta inhibition | [34] |
| 22 | A. flavus OUCMDZ-2205 | the prawn Penaeus vannamei collected in Lianyungang sea area, Jiangsu Province of China | moderate cytotoxicity; nonsignificant antibacterial activity and PKC-beta inhibition | [34] |
| 23 | A. oryzae | the marine sediments collected from Langqi Island, Fujian, China | weak cytotoxic activities against Hela and MGC803 cell lines | [35] |
| 24 | A. oryzae | the marine sediments collected from Langqi Island, Fujian, China | nonsignificant cytotoxic activities against Hela, HL-60, and K562 cell lines | [36] |
| 25 | A. oryzae | the marine sediments collected from Langqi Island, Fujian, China | nonsignificant cytotoxic activities against Hela and MGC803 cell lines | [35] |
| 26 | A. oryzae | the marine sediments collected from Langqi Island, Fujian, China | nonsignificant cytotoxic activities against Hela and MGC803 cell lines | [35] |
| 27 | A. oryzae | the marine sediments collected from Langqi Island, Fujian, China | weak cytotoxic activities against Hela and MGC803 cell lines | [35] |
| 28 | A. oryzae | the marine sediments collected from Langqi Island, Fujian, China | nonsignificant cytotoxic activities against Hela, HL-60, and K562 cell lines | [36] |
| 29 | A. oryzae | the marine sediments collected from Langqi Island, Fujian, China | nonsignificant cytotoxic activities against Hela, HL-60, and K562 cell lines | [36] |
| 30 | A. sp Z-4 | the marine isopod Ligia oceanica collected in Zhoushan, Zhejiang, China | nonsignificant cytotoxicity against PC3 and HCT116 | [37] |
| 31 | A. sulphureus KMM 4640 and I. felina KMM 4639 | marine sediments (no detailed description) | nonsignificant cytotoxic activities against MRC-9, HEK 293T, 22Rv1, PC-3, and LNCaP | [38] |
| 32 | A. sulphureus KMM 4640 and I. felina KMM 4639 | marine sediments (no detailed description) | nonsignificant cytotoxic activities against MRC-9, HEK 293T, 22Rv1, PC-3, and LNCaP | [38] |
| 33 | A. sulphureus KMM 4640 and I. felina KMM 4639 | marine sediments (no detailed description) | nonsignificant cytotoxic activities against MRC-9, HEK 293T, 22Rv1, PC-3, and LNCaP | [38] |
| 34 | A. sulphureus KMM 4640 and I. felina KMM 4639 | marine sediments (no detailed description) | nonsignificant cytotoxic activities against MRC-9, HEK 293T, 22Rv1, PC-3, and LNCaP | [38] |
| 35 | A. sulphureus KMM 4640 and I. felina KMM 4639 | marine sediments (no detailed description) | nonsignificant cytotoxic activities against MRC-9, HEK 293T, 22Rv1, PC-3, and LNCaP | [38] |
| 36 | A. versicolor | the mud of the South China Sea | moderate inhibitory activities against LPS-induced NO production and iNOS enzyme | [40] |
| 37 | A. versicolor | the mud of the South China Sea | moderate inhibitory activities against LPS-induced NO production and iNOS enzyme | [40] |
| 38 | A. versicolor | the mud of the South China Sea | nonsignificant inhibitory activities against LPS-induced NO production and iNOS enzyme | [40] |
| 39 | A. versicolor | the mud of the South China Sea | moderate inhibitory activities against LPS-induced NO production and iNOS enzyme | [40] |
| 40 | A. versicolor | the mud of the South China Sea | potent inhibitory activities against LPS-induced NO production and iNOS enzyme | [40] |
| 41 | A. versicolor | the mud of the South China Sea | nonsignificant inhibitory activities against LPS-induced NO production and iNOS enzyme | [40] |
| 42 | A. versicolor | the mud of the South China Sea | nonsignificant inhibitory activities against LPS-induced NO production and iNOS enzyme | [40] |
| 43 | A. versicolor | the mud of the South China Sea | nonsignificant inhibitory activities against LPS-induced NO production and iNOS enzyme | [40] |
| 44 | A. sp. SF-5976 | an unidentified marine organism collected in the Ross Sea | weak inhibitory activities against LPS-induced NO production in RAW 264.7 and BV2 cells | [41] |
| 45 | A. sp. SF-5976 | an unidentified marine organism collected in the Ross Sea | moderate inhibitory activities against LPS-induced NO production in RAW 264.7 and BV2 cells | [41] |
| 46 | A. versicolor HDN08-60 | the sediments (at a depth of 35 m) collected in the South China Sea, China | nonsignificant cytotoxic activities against HeLa, HCT-116, HL-60 and K562 cell lines | [42] |
| 47 | A. versicolor HDN08-60 | the sediments (at a depth of 35 m) collected in the South China Sea, China | nonsignificant cytotoxic activities against HeLa, HCT-116, HL-60 and K562 cell lines | [42] |
| 48 | A. versicolor HDN08-60 | the sediments (at a depth of 35 m) collected in the South China Sea, China | nonsignificant cytotoxic activities against HeLa, HCT-116, HL-60 and K562 cell lines | [42] |
| 49 | A. versicolor HDN08-60 | the sediments (at a depth of 35 m) collected in the South China Sea, China | nonsignificant cytotoxic activities against HeLa, HCT-116, HL-60 and K562 cell lines | [42] |
| 50 | A. versicolor HDN08-60 | the sediments (at a depth of 35 m) collected in the South China Sea, China | nonsignificant cytotoxic activities against HeLa, HCT-116, HL-60 and K562 cell lines | [42] |
| 51 | A. versicolor HDN08-60 | the sediments (at a depth of 35 m) collected in the South China Sea, China | nonsignificant cytotoxic activities against HeLa, HCT-116, HL-60 and K562 cell lines | [42] |
| 52 | A. sp. SF-5280 | an unidentified sponge collected at Cheju Island, Korea | moderate inhibitory effects against PTP1B activity | [43] |
| 53 | A. violaceofuscus | the inner part of marine sponge Reniochalina sp. collected from Xisha Islands in South China Sea | potent anti-inflammatory activity against IL-10 expression of the LPS-induced THP-1 cells | [44] |
| 54 | A. sp. DX4H | marine shrimp collected in seaside of Dinghai in Zhoushan, Zhejiang Province of China | weak cytotoxic activities against PC3 cell line | [45] |
| 55 | A. sp. DX4H | marine shrimp collected in seaside of Dinghai in Zhoushan, Zhejiang Province of China | weak cytotoxic activities against PC3 cell line | [45] |
| 56 | A. sp. DX4H | marine shrimp collected in seaside of Dinghai in Zhoushan, Zhejiang Province of China | weak cytotoxic activities against PC3 cell line | [45] |
| 57 | A. versicolor HDN08-60 | the sediments (at a depth of 35 m) collected in the South China Sea, China | moderate cytotoxic activities and selective PTK inhibitory activities | [42] |
| 58 | A. versicolor HDN08-60 | the sediments (at a depth of 35 m) collected in the South China Sea, China | nonsignificant cytotoxic activities against HeLa, HL-60, and K562 cell lines | [42] |
| 59 | A. fumigatus SCSIO 41012 | the deep-sea sediments (3614 m) collected from the Indian Ocean | potent antifungal and antibacterial activities | [46] |
| 60 | A. fumigatus SCSIO 41012 | the deep-sea sediments (3614 m) collected from the Indian Ocean | potent antibacterial activities | [46] |
| 61 | A. fumigatus SCSIO 41012 | the deep-sea sediments (3614 m) collected from the Indian Ocean | potent antibacterial activities | [46] |
| 62 | A. sp. CMB-M081F | the marine sediment collected at an intertidal depth of 1 m near Shorncliffe, Queensland, Australia | nonsignificant cytotoxic activities and inhibition on P-glycoprotein-mediated drug efflux | [28] |
| 63 | A. sp. F452 | submerged decaying wood off the shore of Jeju Island, Korea | moderate cytotoxicity; nonsignificant antibacterial activity; weak inhibition against Na+/K+-ATPase | [47] |
| 64 | A. sp. F452 | submerged decaying wood off the shore of Jeju Island, Korea | moderate cytotoxicity; nonsignificant antibacterial activity; weak inhibition against Na+/K+-ATPase | [47] |
| 65 | A. sp. F452 | submerged decaying wood off the shore of Jeju Island, Korea | moderate cytotoxicity; nonsignificant antibacterial activity; weak inhibition against Na+/K+-ATPase | [47] |
| 66 | A. sp. F452 | submerged decaying wood off the shore of Jeju Island, Korea | moderate cytotoxicity; nonsignificant antibacterial activity; weak inhibition against Na+/K+-ATPase | [47] |
| 67 | A. sp. F452 | submerged decaying wood off the shore of Jeju Island, Korea | moderate cytotoxicity; nonsignificant antibacterial activity; weak inhibition against Na+/K+-ATPase | [47] |
| 68 | A. versicolor LZD-14-1 | the gorgonian Pseudopterogorgia sp. (LZD-14) collected from the South China Sea | weak cytotoxic activity against A549; nonsignificant inhibitory activity against TrxR | [33] |
| 69 | A. versicolor LZD-14-1 | the gorgonian Pseudopterogorgia sp. (LZD-14) collected from the South China Sea | weak cytotoxic activity against A549; potent inhibitory activity against TrxR | [33] |
| 70 | A. versicolor LZD-14-1 | the gorgonian Pseudopterogorgia sp. (LZD-14) collected from the South China Sea | weak cytotoxic activity against A549; nonsignificant inhibitory activity against TrxR | [33] |
| 71 | A. versicolor LZD-14-1 | the gorgonian Pseudopterogorgia sp. (LZD-14) collected from the South China Sea | weak cytotoxic activity against A549; nonsignificant inhibitory activity against TrxR | [33] |
| 72 | A. versicolor LZD-14-1 | the gorgonian Pseudopterogorgia sp. (LZD-14) collected from the South China Sea | weak cytotoxic activity against A549; nonsignificant inhibitory activity against TrxR | [33] |
| 73 | A. flocculosus 16D-1 | the inner tissue of marine sponge Phakellia fusca collected from Yongxing Island, China | moderate inhibitory activity against IL-6 production in LPS-induced THP-1 cells | [48] |
| 74 | A. flocculosus 16D-1 | the inner tissue of marine sponge Phakellia fusca collected from Yongxing Island, China | moderate inhibitory activity against IL-6 production in LPS-induced THP-1 cells | [48] |
| 75 | A. flocculosus 16D-1 | the inner tissue of marine sponge Phakellia fusca collected from Yongxing Island, China | moderate inhibitory activity against IL-6 production in LPS-induced THP-1 cells | [48] |
| 76 | A. flocculosus 16D-1 | the inner tissue of marine sponge Phakellia fusca collected from Yongxing Island, China | moderate inhibitory activity against IL-6 production in LPS-induced THP-1 cells | [48] |
| 77 | A. flocculosus 16D-1 | the inner tissue of marine sponge Phakellia fusca collected from Yongxing Island, China | potent inhibitory activity against IL-6 production in LPS-induced THP-1 cells | [48] |
| 78 | A. flocculosus 16D-1 | the inner tissue of marine sponge Phakellia fusca collected from Yongxing Island, China | moderate inhibitory activity against IL-6 production in LPS-induced THP-1 cells | [48] |
| 79 | A. flocculosus 16D-1 | the inner tissue of marine sponge Phakellia fusca collected from Yongxing Island, China | potent inhibitory activity against IL-6 production in LPS-induced THP-1 cells | [48] |
| 80 | A. flocculosus 16D-1 | the inner tissue of marine sponge Phakellia fusca collected from Yongxing Island, China | potent inhibitory activity against IL-6 production in LPS-induced THP-1 cells | [48] |
| 81 | A. flocculosus 16D-1 | the inner tissue of marine sponge Phakellia fusca collected from Yongxing Island, China | moderate inhibitory activity against IL-6 production in LPS-induced THP-1 cells | [48] |
| 82 | A. candidus KUFA0062 | the marine sponge Epipolasis sp. collected at Similan Island National Park (15–20 m), Thailand | weak cytotoxic activity against eight cell lines; nonsignificant antibacterial activity | [25] |
| 83 | A. sclerotiorum and P. citrinum | the gorgonian Muricella flexuosa collected from the South China Sea, Sanya, Hainan Province, China | moderate brine shrimp lethality; nonsignificant antibacterial and anti-biofilm activities | [49] |
| 84 | A. fumigatus | the marine fish Mugil cephalus | cytotoxic tests are in progress | [50] |
| 85 | A. fumigatus | the marine fish Mugil cephalus | cytotoxic tests are in progress | [50] |
| 86 | A. fumigatus | the marine fish Mugil cephalus | cytotoxic tests are in progress | [50] |
| 87 | A. fumigatus | the marine fish Mugil cephalus | cytotoxic tests are in progress | [50] |
| 88 | A. fumigatus | the marine fish Mugil cephalus | cytotoxic tests are in progress | [50] |
| 89 | A. fumigatus | the marine fish Mugil cephalus | cytotoxic tests are in progress | [50] |
| 90 | A. fumigatus | the marine fish Mugil cephalus | cytotoxic tests are in progress | [50] |
| 91 | A. fumigatus | the marine fish Mugil cephalus | cytotoxic tests are in progress | [50] |
| 92 | A. sp. Z-4 | the marine isopod Ligia oceanica collected in seaside of Dinghai in Zhoushan, Zhejiang Province of China | weak cytotoxic activity against PC3 cell line | [51] |
| 93 | A. sp. Z-4 | the marine isopod Ligia oceanica collected in seaside of Dinghai in Zhoushan, Zhejiang Province of China | weak cytotoxic activity against PC3 cell line | [51] |
| 94 | A. sp. Z-4 | the marine isopod Ligia oceanica collected in seaside of Dinghai, Zhejiang Province of China | moderate cytotoxic activities against PC3 and HCT116 cell lines | [52] |
| 95 | A. sp. Z-4 | the marine isopod Ligia oceanica collected in seaside of Dinghai, Zhejiang Province of China | no biological activity was tested | [52] |
| 96 | A. sp. Z-4 | the intestinal of the marine isopod Ligia oceanica | weak cytotoxic activities against PC3 cell line | [53] |
| 97 | A. sp. SCSIOW2 | the deep marine sediment (2439 m) collected in the South China Sea | weak inhibitory activity on NO production induced by lipopolysaccharide (LPS)/INF-γ | [56] |
| 98 | A. violaceofuscus | the inner part of marine sponge Reniochalina sp. collected from Xisha Islands in South China Sea | nonsignificant anti-inflammatory activity against IL-10 expression of the LPS-induced THP-1 cells | [44] |
| 99 | A. violaceofuscus | the inner part of marine sponge Reniochalina sp. collected from Xisha Islands in South China Sea | potent anti-inflammatory activity against IL-10 expression of the LPS-induced THP-1 cells | [44] |
| 100 | A. versicolor ZLN-60 | the mud (depth, 20 m) of the Yellow Sea, China | nonsignificant cytotoxic activities and lipid-lowering effect | [57] |
| A. sp. BM-05 and BM-05ML | a brown algal species belonging to the genus Sargassum collected off Helgoland, North Sea, Germany | moderate cytotoxicities against K562, HCT116, A2780, and A2780CisR cell lines | [58] | |
| 101 | A. versicolor ZLN-60 | the mud (depth, 20 m) of the Yellow Sea, China | nonsignificant cytotoxic activities and lipid-lowering effect | [57] |
| 102 | A. versicolor ZLN-60 | the mud (depth, 20 m) of the Yellow Sea, China | potent lipid-lowering effect; nonsignificant cytotoxic activities | [57] |
| 103 | A. versicolor ZLN-60 | the mud (depth, 20 m) of the Yellow Sea, China | nonsignificant cytotoxic activities and lipid-lowering effect | [57] |
| 104 | A. versicolor ZLN-60 | the mud (depth, 20 m) of the Yellow Sea, China | nonsignificant cytotoxic activities and lipid-lowering effect | [57] |
| 105 | A. terreus SCSGAF0162 | the gorgonian coral Echinogorgia aurantiaca in the South China Sea | nonsignificant antifouling activity towards larvae of the barnacle B. amphitrite | [59] |
| 106 | A. sp. SCSIO 41501 | the gorgonian Melitodes squamata collected from the South China Sea, Sanya, China | moderate antiviral activity against HSV-1 under non-cytotoxic concentrations against Vero cells | [23] |
| 107 | A. similanensis KUFA 0013 | the marine sponge Rhabdermia sp. collected in coral reef of Similan Islands, Phang Nga, Thailand | nonsignificant cytotoxic and antibacterial activities | [60] |
| 108 | A. versicolor TA01-14 | a gorgonian Carijoa sp. GX-WZ-2010001 collected in Weizhou coral reefs in the South China Sea | weak cytotoxic activity; nonsignificant brine shrimp lethality, antibacterial and antiviral activities, as well as AChE, Top I, and α-glucosacharase inhibition | [61] |
| 109 | A. similanensis KUFA 0013 | the marine sponge Rhabdermia sp. collected in coral reef of Similan Islands, Phang Nga, Thailand | weak cytotoxicity; nonsignificant antibacterial activities against four reference strains | [60] |
| 110 | A. niger SCSIO Jcsw6F30 | a marine alga Sargassum sp. collected in Yongxing Island, South China Sea | potent cytotoxic activity against TZM-bl cells; moderate anti-HIV-1 activity against HIV-1 SF162 | [62] |
| 111 | A. niger SCSIO Jcsw6F30 | a marine alga Sargassum sp. collected in Yongxing Island, South China Sea | no biological activity was tested | [62] |
| 112 | A. sp. XS20090B15 | the Muricella abnormaliz gorgonian collected from the Xisha Islands coral reef in South China Sea | nonsignificant antiviral activity against RSV virus-induced cytopathogenicity in Hep-2 cells | [63] |
| 113 | A. sp. XS20090B15 | the Muricella abnormaliz gorgonian collected from the Xisha Islands coral reef in South China Sea | potent antiviral activity against RSV virus-induced cytopathogenicity in Hep-2 cells | [63] |
| 114 | A. versicolor A-21-2-7 | the deep-sea sediment (3002 m) in South China Sea | no biological activity was tested | [64] |
| 115 | A. flavus KMM 4650 | Sakhalin Bay marine sediments (32 m, Sea of Okhotsk) | nonsignificant antimicrobial activity | [65] |
| 116 | A. versicolor | the inner part of gorgonian D. gemmacea collected from the Xisha Islands coral reef of the South China Sea | moderate antibacterial activities and brine shrimp lethality; nonsignificant cytotoxicities | [66] |
| 117 | A. versicolor | the inner part of gorgonian D. gemmacea collected from the Xisha Islands coral reef of the South China Sea | moderate antibacterial activities and brine shrimp lethality; nonsignificant cytotoxicities | [66] |
| 118 | A. ochraceus LCJ11-102 | the gorgonian Dichotella gemmacea (Valenciennes) collected in Lingao, Hainan province of China | moderate antimicrobial activity against E. aerogenes; nonsignificant cytotoxic activities | [67] |
| 119 | A. ochraceus LCJ11-102 | the gorgonian Dichotella gemmacea (Valenciennes) collected in Lingao, Hainan province of China | nonsignificant antimicrobial and cytotoxic activities | [67] |
| 120 | A. ochraceus LCJ11-102 | the gorgonian Dichotella gemmacea (Valenciennes) collected in Lingao, Hainan province of China | nonsignificant antimicrobial and cytotoxic activities | [67] |
| 121 | A. ochraceus LCJ11-102 | the gorgonian Dichotella gemmacea (Valenciennes) collected in Lingao, Hainan province of China | moderate antimicrobial activity against E. aerogenes; nonsignificant cytotoxic activities | [67] |
| 122 | A. ochraceus LCJ11-102 | the gorgonian Dichotella gemmacea (Valenciennes) collected in Lingao, Hainan province of China | nonsignificant antimicrobial and cytotoxic activities | [67] |
| 123 | A. sclerotiorum and P. citrinum | the gorgonian Muricella flexuosa collected from the South China Sea, Sanya, Hainan Province, China | potent brine shrimp lethality and cytotoxic activities; nonsignificant antibacterial and anti-biofilm activities | [49] |
| 124 | A. sclerotiorum and P. citrinum | the gorgonian Muricella flexuosa collected from the South China Sea, Sanya, Hainan Province, China | moderate brine shrimp lethality and cytotoxic activities; nonsignificant antibacterial and anti-biofilm activities | [49] |
| 125 | A. sp. (33241) | the mangrove Bruguiera sexangula var. rhynchopetala collected in the South China Sea | nonsignificant antibacterial and cytotoxic activities | [68] |
| 126 | A. terreus FA009 | the marine sediment collected in Jeju Island, Korea | moderate enhancement effect on insulin sensitivity | [69] |
| 127 | A. terreus FA009 | the marine sediment collected in Jeju Island, Korea | moderate enhancement effect on insulin sensitivity | [69] |
| 128 | A. sclerotiorum and P. citrinum | the gorgonian Muricella flexuosa collected from the South China Sea, Sanya, Hainan Province, China | weak brine shrimp lethality; nonsignificant cytotoxic, antibacterial and anti-biofilm activities | [49] |
| 129 | A. sydowii SP-1 | the marine sediment sample collected from site in the Antarctic Great Wall Station | weak antimicrobial activities against MRSA and MRSE | [70] |
| 130 | A. sp. WU 243 | the crab Xenograpsus testudinatus collected from a Kueishantao hydrothermal vent, Taiwan, China | no biological activity was tested | [71] |