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COS regulates lipogenesis-related genes in the liver of T2DM mice. (A,B) The mRNA and protein levels of the HMGCR, CYP7A1, and SMYD3 in liver were detected by RT-qPCR and western blotting. (C,D) The mRNA and protein levels of GLP-1 and SMYD3 in intestine were detected by RT-qPCR and western blotting. Data are presented as mean ± SD (n = 8); * p < 0.05 and ** p < 0.01, compared with the NFD group; # p < 0.05 and ## p < 0.01, compared with the T2DM group.
