Table 1.
Key physical and chemical properties of triclosan.
| Parameters | Triclosan (TCS) |
|---|---|
| Chemical structure |
|
| Molecular formula | C12H7Cl3O2 |
| Molecular weight (g/mol) | 289.536 |
| CAS registration number | 3380-34-5 |
| IUPAC name | 2,4,4′-trichloro-2′-hydroxydiphenyl ether or 5-chloro-2-(2,4-dichlorophenoxy)phenol |
| Trade name | Irgasan DP300 or CH 3565 |
| Use | Antiseptic and disinfectant |
| Chlorine content (weight %) | 33.7 a |
| Log Kow (at 25 °C, pH 7) | 4.8 a |
| Log Koc (at 25 °C, pH 7) | 4.1 b |
| pKa (at 20 °C) | 8.14 c |
| Melting point (°C) | 54 – 57 c |
| Boiling point (°C) | 280–290 d |
| Water solubility (mg/L at 25 °C) | 1.97–4.6 a |
| Vapour pressure (mm Hg at 25 °C) | 4.65 × 10−6 e |
| Some of potential transformation products f,g h,i,j | Methyl-triclosan 2,4-dichlorophenol 2,4,6-trichlorophenol 2,3,4-trichlorophenol 2,8-dichlorodibenzo-p-dioxin Triclosan O-β-d-glucuronide Triclosan-O-Sulfate Tetra-III Penta Chloroform |
Log Kow: The logarithmic octanol-water partition coefficient, Log Koc: Organic carbon partition coefficient, pKa: Dissociation constant. a Halden and Paull [11], b Heidler and Halden [12], c Reiss et al. [13], d Dann and Hontela [14], e Ying et al. [15], f Tohidi and Cai [16], g Chen et al. [17], h Armstrong et al. [18], i Dann and Hontela [14], j Canosa et al. [19].