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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Curr Opin Infect Dis. 2019 Jun;32(3):204–209. doi: 10.1097/QCO.0000000000000550

Figure 1: Macrophage phenotype functional diversity in the wound-healing environment.

Figure 1:

Graphical representation of macrophage functional phenotypes follow normal wound healing progression from post-injury recruitment of circulating innate immune cells to localized macrophage differentiation (M0: Resting Macrophage, yellow cells). Activation of macrophage polarization may result in one of five distinct functional phenotypes as follows: M1 Inflammatory Macrophages (red cells), M2a Anti-Inflammatory Macrophages (dark blue cells), M2b Tissue Remodeling Macrophages (purple cells), M2c Tissue Repair Macrophages (orange cells), or M2d Tumor Associated Macrophages (light blue cells).

Source: Original art by co-author Tyler Lawton.