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. Author manuscript; available in PMC: 2020 Aug 15.
Published in final edited form as: Cancer Res. 2019 Dec 5;80(4):709–718. doi: 10.1158/0008-5472.CAN-18-2808

Figure 2.

Figure 2.

PP242 inhibits mTOR, PKCα, and STAT3. A, Cartoon: PP242 inhibits PKCα, JAK2, and p110γ in addition to mTOR, whereas sapanisertib and KU-0063794 do not. B and C, LN229 parent, GBM43, and GBM34 cells were treated with KU-0063794, PP242, and sapanisertib at indicated doses for 24 hours. PTEN and EGFR status in glioma cell lines is shown (wt, wild type). Cells were harvested, lysed, and analyzed by western blot with indicated antibodies. TPA (100 nM) or OSM (25 ng/ml) were added 30 minutes before harvest.