Figure 4.

Retigabine triggers a contractile response in malignant hyperthermia‐susceptible (MHS; susceptible subjects) but not in malignant hyperthermia‐negative (MHN; negative subjects) biopsies. (a) Representative trace of skeletal muscle bundle obtained from MHN subjects incubated with retigabine (1 mM) for 15 min. (b) Representative trace of skeletal muscle bundle obtained from MHS subjects incubated with retigabine for 15 min. Retigabine increases the contracture in MHS but not in MHN bundles, n = 5 for MHN biopsies and n = 4 for MHS biopsies. (c) Effect of retigabine incubation, expressed as an increased tension, in MHN and MHS biopsies. The value enclosed in red circleindicates the established threshold for susceptibility diagnosis