Table 2.
Characteristics of Cases at the Index Date
| Characteristic | Herpes Zoster Cases, N=2271 (%) | Hepatitis C Cases, N=150 (%) | Tuberculosis Cases, N=81 (%) |
|---|---|---|---|
| Age at index date | |||
| Less than 40 years | 283 (12.5) | 7 (4.7) | 16 (19.8) |
| 40–49 years | 421 (18.5) | 13 (8.7) | 18 (22.2) |
| 50–59 years | 785 (34.6) | 63 (42.0) | 22 (27.2) |
| 60–69 years | 580 (25.5) | 62 (41.3) | 15 (18.5) |
| ≥70 years | 202 (8.9) | 5 (3.3) | 10 (12.4) |
| Median (years) | 56 | 58 | 53 |
| Sex | |||
| Female | 1386 (61.0) | 43 (28.7) | 39 (48.2) |
| Male | 885 (39.0) | 107 (71.3) | 42 (51.9) |
| Index year | |||
| 2014 | 357 (15.7) | 35 (23.3) | 14 (17.3) |
| 2015 | 472 (20.8) | 52 (34.7) | 21 (25.9) |
| 2016 | 535 (23.6) | 34 (22.7) | 19 (23.5) |
| 2017 | 528 (23.2) | 20 (13.3) | 19 (23.5) |
| 2018 | 379 (16.7) | 9 (6.0) | 8 (9.9) |
| Indication at index date | |||
| PsA (with or without psoriasis) | 1268 (55.8) | 73 (48.7) | 43 (53.1) |
| Psoriasis | 1003 (44.2) | 77 (51.3) | 38 (46.9) |
| Psoriasis/PsA disease duration before index date | |||
| <1 year | 148 (6.5) | 11 (7.3) | 9 (11.1) |
| 1–<3 years | 336 (14.8) | 12 (8.0) | 6 (7.4) |
| 3–<5 years | 266 (11.7) | 12 (8.0) | 6 (7.4) |
| ≥5 years | 423 (18.6) | 18 (12.0) | 15 (18.5) |
| Unknown | 1098 (48.4) | 97 (64.7) | 45 (55.6) |
| Median (years), excluding unknown | 3.1 | 2.6 | 7.3 |
| Infection risk factors before index date | |||
| Diabetes | 532 (23.4) | 30 (20.0) | 22 (27.2) |
| Chronic obstructive pulmonary disease and other lung diseases* | 522 (23.0) | 25 (16.7) | 17 (21.0) |
| Heart failure | 116 (5.1) | 9 (6.0) | 5 (6.2) |
| Angina | 82 (3.6) | 5 (3.3) | 0 (0.0) |
| Gastrointestinal ulcer | 59 (2.6) | 4 (2.7) | 2 (2.5) |
| Dementia | 5 (0.2) | 0 (0.0) | 0 (0.0) |
| Crohn’s disease | 127 (5.6) | 8 (5.3) | 8 (9.9) |
| Ulcerative colitis | 96 (4.2) | 4 (2.7) | 3 (3.7) |
| Diffuse diseases of connective tissue* | 157 (6.9) | 5 (3.3) | 1 (1.2) |
| Multiple sclerosis | 19 (0.8) | 0 (0.0) | 0 (0.0) |
| Rheumatoid arthritis | 484 (21.3) | 16 (10.7) | 15 (18.5) |
| Peripheral vascular disease | 108 (4.8) | 2 (1.3) | 2 (2.5) |
| Infection risk factors within 60 days before index date | |||
| Other immunosuppressant use | 127 (5.6) | 3 (2.0) | 3 (3.7) |
| Any fracture | 21 (0.9) | 2 (1.3) | 2 (2.5) |
| Surgical procedures (major or minor) ** | 526 (23.2) | 51 (34.0) | 32 (29.5) |
| Ventilator use | 0 (0.0) | 0 (0.0) | 0 (0.0) |
| Urinary catheter use | 0 (0.0) | 0 (0.0) | 0 (0.0) |
| Pressure ulcer | 4 (0.2) | 1 (0.7) | 0 (0.0) |
| Diagnosis or treatment for malignant neoplasm | 75 (3.3) | 7 (4.7) | 0 (0.0) |
Notes: *Chronic obstructive pulmonary disease and other lung diseases included asthma, bronchitis, emphysema, bronchiectasis and pneumoconiosis. Diffuse diseases of connective tissue included systemic lupus erythematosus, dermatopolymyositis, systemic sclerosis and other systemic disorders of connective tissue. **Includes all major and minor surgical procedures CPT codes 100021–69990, excluding venous and capillary blood specimen collection CPT codes 36415 and 36416.