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. 2020 Feb;70(1):56–66. doi: 10.30802/AALAS-CM-18-000134

Figure 5.

Figure 5.

Effect of varying the drug treatment regimen. Data shown indicate the effect of (A) decreasing the duration of ganciclovir or cidofovir, (B) delaying the start of ganciclovir or cidofovir treatment, or (C) varying the concentration of cidofovir on the survival of mice to 14 dpi. Cidofovir was 100% protective when administered only on the day of infection, whereas ganciclovir had to be administered for at least 5 d to be 100% protective. Delaying the initiation of cidofovir and ganciclovir treatment only 24 h after infection resulted in a decrease in efficacy. In panels A and B: gray, 5% ganciclovir; black, 0.5% cidofovir. In panel C: black, 3% cidofovir; gray, 1% cidofovir; white, 0.5% cidofovir.