Figure 8.

Efficacy of ganciclovir and cidofovir against ganciclovir-resistant BV. Mice were infected with (A and D) 10 LD₅₀ (2 × 10⁵ pfu) of wildtype BV or (B and E) 2 × 10⁵ pfu or (C and F) 2 × 10⁶ pfu of a ganciclovir-resistant BV mutant. Mice were treated with vehicle only (circles with solid line), 5% ganciclovir (squares with dashed line), or 0.5% cidofovir (triangles with dotted line). The (A through C) group neurologic score and (D through F) percentage of mice showing skin lesions are shown.