Table 1.
Neurologic score |
|||
Maximum | Survivors at 14 dpi | ||
Topical ganciclovir | |||
0% (control) | 5 (5, 5); n = 23 | no survivors | |
0.1% | 5 (5, 5); n = 28 | 0 (0, 0); n = 6 | |
0.3% | 5 (5, 5); n = 28 | 0 (0, 0.5); n = 6 | |
0.5% | 5 (2, 5); n = 28 | 1.5 (0, 2); n = 11 | |
1% | a3 (1, 5); n = 28 | 0.5 (0, 2); n = 19 | |
3% | a1.75 (0, 2.9); n = 28 | 0 (0, 1); n = 28 | |
5% | *0 (0, 1); n = 28 | 0 (0, 0); n = 28 | |
% cidofovir | |||
0% (control) | 5 (5, 5); n = 15 | no survivors | |
0.001% | 5 (5, 5); n = 20 | no survivors | |
0.003% | 5 (5, 5); n = 20 | 0 (0, 0); n = 4 | |
0.005% | 5 (5, 5); n = 10 | no survivors | |
0.01% | 0.5 (0, 5); n = 20 | 0 (0, 0); n = 13 | |
0.03% | a0 (0, 0); n = 20 | 0 (0, 0); n = 18 | |
0.05% | a0 (0, 0); n = 10 | 0 (0, 0); n = 10 | |
0.1% | a0 (0, 0.75); n = 20 | 0 (0, 0); n = 16 | |
0.3% | a0 (0, 0); n = 20 | 0 (0, 0); n = 20 | |
1% | a0 (0, 0); n = 9 | 0 (0, 0); n = 9 | |
3% | a0 (0, 0); n = 9 | 0 (0, 0); n = 9 | |
5% | a0 (0, 0); n = 9 | 0 (0, 0); n = 9 |
Data are presented as the median (lower quartile, upper quartile); number of mice in group.
Value is significantly (P < 0.05) different from maximal neurologic score of control mice.