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. 2020 Feb 11;13:97–110. doi: 10.2147/RMHP.S230953

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© 2020 Cepeda et al.

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Percentage of Chromosomal Instability (CIN) observed in peripheral blood lymphocytes (PBLs) from farmers exposed to pesticides and from unexposed individuals. CIN was evaluated on nuclei spreads by using FISH with six centromeric probes (CEP) for chromosomes 2, 3, 8, 11, 15 and 17. The CIN rate for each exposed and unexposed individual was defined first by calculating the percentage of nuclei with a CEP signal number different to the modal number (most common chromosome number in a tumor cell population) for each individual chromosome and then calculating the mean CIN percentage of all chromosomes analyzed. The bars indicate the mean and standard deviation of each probe in each group (exposed and unexposed).