Table 3.

KEGG Pathway Enrichment Results of DEGs

KEGG Pathway	Count	P value	Enriched Genes	Fold Enrichment
hsa04640:Hematopoietic cell lineage	11	5.74E-05	CSF3, IL1R1, IL6, CD44, ITGA5, IL1B, CSF3R, IL7R, ITGAM, CD14, IL11	4.964938754
hsa04620:Toll-like receptor signaling pathway	12	4.48E-05	CD86, IL6, LY96, TLR1, TLR2, IL1B, TLR4, CXCL11, CCL4, TLR8, CD14, SPP1	4.611896304
hsa04610:Complement and coagulation cascades	8	0.0017529	C3AR1, C5AR1, THBD, F5, SERPINE1, TFPI, C1S, PLAU	4.500497843
hsa04060:Cytokine-cytokine receptor interaction	29	4.21E-11	CSF3, IL1R1, CXCL5, OSMR, CCR1, CXCR2, CXCL6, IL7R, CXCL11, CCL4, IL10, IL11, TNFRSF11B, TNFRSF1B, IL1RAP, IL1B, CSF2RB, CSF3R, IL18R1, IL6, FLT1, IL18RAP, IL24, HGF, OSM, INHBA, VEGFC, TNFRSF10C, PDGFRA	4.296515355
hsa04512:ECM-receptor interaction	7	0.0198722	COL4A2, COL4A1, CD44, ITGA5, TNC, LAMC1, SPP1	3.234732824
hsa04630:Jak-STAT signaling pathway	12	0.0018871	OSM, CSF3, IL6, OSMR, SOCS3, CSF2RB, CSF3R, IL24, IL7R, IL10, IL11, IL13RA2	3.00517114
hsa04210:Apoptosis	6	0.0709049	IRAK3, IL1R1, TNFRSF10C, IL1RAP, CSF2RB, IL1B	2.677020268
hsa04514:Cell adhesion molecules (CAMs)	9	0.0191196	ICAM1, SELP, CD86, SELL, PECAM1, VCAN, SELE, CDH5, ITGAM	2.646599584
hsa04510:Focal adhesion	11	0.0321302	VEGFC, CAV1, COL4A2, FLT1, COL4A1, ITGA5, TNC, PDGFRA, HGF, LAMC1, SPP1	2.124302153
hsa04062:Chemokine signaling pathway	10	0.0490143	ARRB2, FGR, CXCL5, PREX1, CCR1, HCK, CXCR2, CXCL6, CXCL11, CCL4	2.075764379
hsa04010:MAPK signaling pathway	12	0.0783446	MAP4K4, DUSP4, IL1R1, DUSP2, ARRB2, DUSP14, PDGFRA, HSPA6, IL1B, GADD45B, FGF2, CD14	1.744575006

Notes: KEGG biological pathway enrichment analysis found that Toll-like receptor signaling pathway (P-value <0.0001, count =12, and fold enrichment =4.61) was the most important one among the eleven significantly enriched pathways.

Abbreviation: KEGG, Kyoto Encyclopedia of Genes and Genomes.