Table 2.
Data inputs and model assumptions
| Point estimate (95% CI) | Source | |
|---|---|---|
| Population characteristics | ||
| Annual global BCG eligible birth cohort | 129·1 million | 9 |
| Annual all-cause childhood deaths in birth cohort in children aged 0–4 years | 6·8 million | 11 |
| Annual all-cause childhood deaths in birth cohort in children aged 5–9 years | 643 000 | 11 |
| Annual all-cause childhood deaths in birth cohort in children aged 10–14 years | 560 000 | 11 |
| HIV-negative paediatric male tuberculosis deaths in 2016 | 110 000 (75 000–151 000) | 13 |
| HIV-negative paediatric female tuberculosis deaths in 2016 | 91 000 (60 000–129 000) | 13 |
| Tuberculosis deaths in children younger than 5 years who had received tuberculosis treatment in 2015 (HIV negative) | 2690 (1850–4180) | 14 |
| Tuberculosis deaths in children younger than 5 years who had not received tuberculosis treatment in 2015 (HIV negative) | 161 000 (108 000–223 000) | 14 |
| Tuberculosis deaths in children aged 5–15 years who had received tuberculosis treatment in 2015 (HIV negative) | 2050 (1510–3100) | 14 |
| Tuberculosis deaths in children aged 5–15 years who had not received tuberculosis treatment in 2015 (HIV negative) | 31 500 (18 600–51 400) | 14 |
| Vaccine characteristics | ||
| Vaccine efficacy against tuberculosis death, % | 66% (8–88) | 3 |
| Vaccine efficacy by age at administration | Constant regardless of age of administration | Assumption |
| Duration of protection | 15 years | 21 |
| Waning of protection | None | Assumption |