Fig. 4.

rs2203712 in the CELF1 gene region is associated with higher fractional anisotropy (FA) in amyloid-positive participants, as classified by CSF Aβ levels. (A) The presence of at least one copy of the minor allele (T) of rs2203712 was significantly associated with increased FA in hippocampus (p = 0.001). (B) The effect of the common C allele on fractional anisotropy was present in both amyloid-negative (left column) and amyloid-positive (right column) participants. rs2203712 is significantly associated with FA in amyloid-positive participants (p = 0.004). Each participant was classified by their amyloid status (positive versus negative) at the last visit (determined by standard cutoffs on CSF amyloid levels).