Table 2a.
Known pathways enriched in the gene modules significantly correlated with DTI-features in specific brain regions. The column Corrected p-value shows corrected p values for the Spearman's rank correlation between the indicated DTI feature and gene expression module.
| Region | DTI Feature | Coexpression Module | Enriched Pathways | Corrected p-value |
|---|---|---|---|---|
| Superior occipital gyrus right | FA | M30 | immune response, response to cytokine, cytokine-mediated signaling pathway, innate immune response, regulation of immune system process | 1.34 × 10−2 |
| Supramarginal gyrus left | PLA | M30 | immune response, response to cytokine, cytokine-mediated signaling pathway, innate immune response, regulation of immune system process | 1.62 × 10−2 |
| Supramarginal gyrus right | PLA | M30 | immune response, response to cytokine, cytokine-mediated signaling pathway, innate immune response, regulation of immune system process | 2.16 × 10−2 |
| Supramarginal gyrus left | LIN | M30 | immune response, response to cytokine, cytokine-mediated signaling pathway, innate immune response, regulation of immune system process | 2.70 × 10−2 |
| Postcentral gyrus right | PLA | M30 | immune response, response to cytokine, cytokine-mediated signaling pathway, innate immune response, regulation of immune system process | 2.97 × 10−2 |
| Supramarginal gyrus right | MD | M30 | immune response, response to cytokine, cytokine-mediated signaling pathway, innate immune response, regulation of immune system process | 3.24 × 10−2 |
| Supramarginal gyrus right | RD | M30 | immune response, response to cytokine, cytokine-mediated signaling pathway, innate immune response, regulation of immune system process | 3.38 × 10−2 |
| Corticospinal tract left | ODI | M18 | Sensory perception, nervous system process and G-protein coupled receptor signaling pathway | 3.92 × 10−2 |
| Inferior fronto occipital fasciculus right | ODI | M145 | Cell-cell adhesion, IRE1-mediated unfolded protein response, RNA interference and posttranscriptional regulation of gene expression | 4.32 × 10−2 |
| Supramarginal gyrus right | L1 | M30 | immune response, response to cytokine, cytokine-mediated signaling pathway, innate immune response, regulation of immune system process | 4.32 × 10−2 |
| Fusiform WM left | MD | M26 | immune response, response to cytokine, cytokine-mediated signaling pathway, innate immune response, regulation of immune system process | 4.46 × 10−2 |
| Medulla right | MOD | M23 | cell surface receptor signaling pathway, neurotrophin TRK receptor signaling pathway, B cell activation, cell differentiation, regulation of response to stimulus and cellular developmental process | 8.51 × 10−3 |