Average estimated prevalence of cold-evoked pain in different human pain states. Data points represent the prevalence of pain evoked by cooling or cold stimuli reported among chronic pain patients in individual clinical studies (Baron et al., 2009, Bécouarn et al., 1998, Bengtsson et al., 1986, Bowsher, 2005, Cersosimo, 2005, Craigen et al., 1999, de Gramont et al., 2000, Díaz-Rubio et al., 1998, Dougherty et al., 2004, Forsyth et al., 1997, Halawa et al., 2010, Irwin et al., 1997, Kim and Choi-Kwon, 1999, Koroschetz et al., 2011, Lange et al., 1992, Laugier et al., 1979, Lawrence et al., 1980, Lithell et al., 1998, Machover et al., 1996, Nijhuis et al., 2010, Nurmikko et al., 1990, Ruijs et al., 2007, Toth et al., 2009, Vestergaard et al., 1995).